Remdesivir-d4

• Description :

  Remdesivir-d4 (GS-5734-d4) is deuterium labeled Remdesivir (HY-104077) . Remdesivir (GS-5734) is a nucleoside analogue with effective antiviral activity. Remdesivir can inhibit the synthesis of viral DNA or RNA. Remdesivir can be used for the research of infection, such as SARS-CoV and MHV infection[1][2][3].

• Product Name Alternative :

  GS-5734-d4

• UNSPSC :

  12352005

• Target :

  DNA/RNA Synthesis; Isotope-Labeled Compounds; SARS-CoV

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage; Others

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(OCC(CC)CC)[C@@](C([2H])([2H])[2H])([2H])N[P@@](OC1=CC=CC=C1)(OC[C@H]2O[C@@](C#N)(C3=CC=C4C(N)=NC=NN43)[C@H](O)[C@@H]2O)=O

• Molecular Formula :

  C27H31D4N6O8P

• Molecular Weight :

  606.60

• References & Citations :

  [1]Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9 (2) . pii: e00221-18.|[2]Wang M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30 (3) :269-271.|[3]Hu H, et al. Optimization of the Prodrug Moiety of Remdesivir to Improve Lung Exposure/Selectivity and Enhance Anti-SARS-CoV-2 Activity. J Med Chem. 2022 Sep 22;65 (18) :12044-12054.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported