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Remdesivir

CAT: 0804-HY-104077-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-104077-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Remdesivir (GS-5734) is a nucleoside analogue with effective antiviral activity. Remdesivir can inhibit the synthesis of viral DNA or RNA. Remdesivir can be used for the research of infection, such as SARS-CoV and MHV infection[1][2][3].
CAS Number
1809249-37-3
Product Name Alternative
GS-5734
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335, H373
Target
DNA/RNA Synthesis; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Remdesivir.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@H](N[P@@](OC1=CC=CC=C1)(OC[C@H]2O[C@@](C#N)(C3=CC=C4C(N)=NC=NN43)[C@H](O)[C@@H]2O)=O)C(OCC(CC)CC)=O
Molecular Formula
C27H35N6O8P
Molecular Weight
602.58
Precautions
H302, H315, H319, H335, H373
References & Citations
[1]Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9 (2) . pii: e00221-18.|[2]Wang M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30 (3) :269-271.|[3]Hu H, et al. Optimization of the Prodrug Moiety of Remdesivir to Improve Lung Exposure/Selectivity and Enhance Anti-SARS-CoV-2 Activity. J Med Chem. 2022 Sep 22;65 (18) :12044-12054.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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