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HJC0197

CAT: 0804-HY-117958-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117958-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP[1].
CAS Number
1383539-73-8
Product Name Alternative
CP21
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/hjc0197.html
Purity
99.62
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 1.67 mg/mL
Smiles
N#CC1=C(C2CCCC2)N=C(SCC3=CC(C)=CC=C3C)NC1=O
Molecular Formula
C19H21N3OS
Molecular Weight
339.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Chen H, et al. 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. Bioorg Med Chem Lett. 2012 Jun 15;22 (12) :4038-43.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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