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HMG499

CAT: 0804-HY-114316-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114316-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC50 of 0.41 μM. HMG499 can prevent statins-induced accumulation of HMGCR, reduce serum cholesterol levels and decrease atherosclerosis[1].
CAS Number
2416941-68-7
Product Name Alternative
AM152, AM152 (sodium)
UNSPSC
12352211
Target
Autophagy; HMG-CoA Reductase (HMGCR)
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/HMG499.html
Purity
96.78
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
C[C@H](CCCC(CC=C)(CC=C)O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C=C4C(C)(C)[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Molecular Formula
C33H54O3
Molecular Weight
498.78
References & Citations
[1]Jiang SY, et al. Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol. Nat Commun. 2018 Dec 3;9 (1) :5138.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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