Polyquaternium-1

CAT: 0804-HY-127032-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-127032-01Size:5 mg
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Description
Polyquaternium-1 (Polidronium chloride; PQ-1) is an antimicrobial preservative and an activator of NF-κB. Polyquaternium-1 targets bacterial cell membranes, commonly used in ophthalmic surgery. Polyquaternium-1 adsorbs to the surface of microbial membranes through its polycationic properties, destroying membrane integrity and inducing potassium ion leakage, leading to bacterial death. Polyquaternium-1 exerts antimicrobial effects at a concentration of 0.001% and has low toxicity to mammalian cells. Polyquaternium-1 can be used to prepare products such as glaucoma eye drops (Travoprost preparations containing PQ-1), artificial tears, and contact lens solutions to reduce the ocular surface toxicity of traditional preservatives such as benzalkonium chloride (HY-B2232) [1][2][3].
CAS Number
[75345-27-6]
Product Name Alternative
Polidronium (chloride)
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/polyquaternium-1.html
Purity
99.0
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
OCC[N+](CCO)(C/C=C/C[N+](C)(C/C=C/C[N+](CCO)(CCO)CCO)C)CCO.[3Cl-].[n]
Molecular Formula
(C6H12N) nC16H36N2O6.3Cl
Precautions
H315, H319, H335
References & Citations
[1]Paimela T, et al. The preservative polyquaternium-1 increases cytoxicity and NF-kappaB linked inflammation in human corneal epithelial cells. Mol Vis. 2012;18:1189-96. Epub 2012 May 6.|[2]Rolando M, et, al. Ophthalmic preservatives: focus on polyquaternium-1. Expert Opin Drug Deliv. 2011 Nov;8 (11) :1425-38.|[3]Mohamed YH, et al. Acute Corneal Toxicity of Combined Antiglaucoma Topical Eyedrops. Curr Eye Res. 2016 Oct;41 (10) :1326-1330.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 4

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