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Ditercalinium (chloride)

CAT: 0804-HY-19587-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19587-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ditercalinium chloride is an anticancer agent. Ditercalinium chloride inhibits human DNA polymerase gamma activity. Ditercalinium chloride can deplete mitochondrial DNA in both mouse and human cells. Ditercalinium chloride is a potential ligand against the COMMD10-AP3S1 fusion protein[1][2].
CAS Number
74517-42-3
Product Name Alternative
NSC335153
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ditercalinium-chloride.html
Purity
96.12
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC1=CC2=C(NC3=C2C4=C[N+](CCN5CCC(C6CCN(CC[N+]7=CC=C8C=CC(NC9=C%10C=C(OC)C=C9)=C%10C8=C7)CC6)CC5)=CC=C4C=C3)C=C1.[Cl-].[Cl-]
Molecular Formula
C46H50Cl2N6O2
Molecular Weight
789.83
References & Citations
[1]Okamaoto M, et al. Ditercalinium chloride, a pro-anticancer drug, intimately associates with mammalian mitochondrial DNA and inhibits its replication. Curr Genet. 2003 Aug;43 (5) :364-70. |[2]Sandhya Rai, et al. Ditercalinium chloride: A potential inhibitor targeting recurrent in frame COMMD10-AP3S1 fusions in CRCs. Gene Reports. 2023, 30:101739.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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