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Azumolene (sodium)

CAT: 0804-HY-113920Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-113920Size:1 Each
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Description
Azumolene sodium (EU4093) is an analog of Dantrolene that inhibits malignant hyperthermia (MH) syndrome and intracellular Ca2+ homeostasis failure caused by Halothane (HY-B1010) /Succinylcholine. Azumolene sodium (0.5-2.0 mg/kg) reduces [Ca2+]i (from 207 nM to 38 nM) in MH-susceptible skeletal muscle following intramuscular injection[1].
CAS Number
105336-14-9
Product Name Alternative
EU4093
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/azumolene-sodium.html
Solubility
10 mM in DMSO
Smiles
O=C1NC(CN1/N=C/C2=NC=C(C3=CC=C(Br)C=C3)O2)=O.[Na]
Molecular Formula
C13H9BrN4NaO3
Molecular Weight
372.13
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Allen P D, Lopez J R, Sanchez V, et al. EU 4093 decreases intracellular [Ca2+] in skeletal muscle fibers from control and malignant hyperthermia-susceptible swine[J]. Anesthesiology, 1992, 76 (1) : 132-138.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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