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FH1

CAT: 0804-HY-12346-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12346-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FH1 (NSC 12407) is a NQO2 inhibitor with hepatoprotective effects. FH1 enhances hepatocyte function and promotes differentiation of induced pluripotent stem (iPS) -derived hepatocytes to a more mature phenotype and maturation of well-differentiated hepatocyte-like cell (iHeps) cultures. FH1 protects against Acetaminophen -induced hepatotoxicity in both embryos and adult zebrafish[1][2][3].
CAS Number
2719-05-3
Product Name Alternative
NSC 12407; BRD-K4477
UNSPSC
12352005
Hazard Statement
H400
Target
Quinone Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/FH1.html
Purity
99.17
Solubility
DMSO : 13 mg/mL (ultrasonic; warming)
Smiles
CC(NC1=CC=C(CC2=CC=C(NC(C)=O)C=C2)C=C1)=O
Molecular Formula
C17H18N2O2
Molecular Weight
282.34
Precautions
H400
References & Citations
[1]Shan J, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat Chem Biol. 2013 Aug;9 (8) :514-20.|[2]Lunzhi Yuan, et al. A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cell for the Chronic Hepatitis B Virus Infection. Front Microbiol. 2018 May 8;9:908.|[3]Schepers AG, et al. Identification of NQO2 As a Protein Target in Small Molecule Modulation of Hepatocellular Function. ACS Chem Biol. 2021 Sep 17;16 (9) :1770-1778.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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