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Giredestrant

CAT: 0804-HY-109176-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109176-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Giredestrant (GDC-9545), a non-steroidal estrogen receptor (ER) ligand, is an orally active and selective ER antagonist. Giredestrant potently competes with Estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity[1].
CAS Number
1953133-47-5
Product Name Alternative
GDC-9545; RG6171
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/giredestrant.html
Purity
99.52
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OCC(F)(F)CN([C@@H]1C2=C(F)C=C(NC3CN(CCCF)C3)C=C2F)[C@H](C)CC4=C1NC5=C4C=CC=C5
Molecular Formula
C27H31F5N4O
Molecular Weight
522.55
Precautions
H302, H315, H319
References & Citations
[1]C Metcalfe, et al. Abstract P5-04-07: GDC-9545: A novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
Estrogen receptor

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