SC-VC-PAB-MMAE

• UNSPSC Description:

  SC-VC-PAB-MMAE is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker SC-VC-PAB[1].

• Target Antigen:

  Drug-Linker Conjugates for ADC

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sc-vc-pab-mmae.html

• Purity:

  99.29

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCC(ON1C(CCC1=O)=O)=O)=O)=O)NC(C=C2)=CC=C2COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N3[C@H]([C@H](OC)[C@@H](C)C(N[C@@H]([C@@H](O)C4=CC=CC=C4)C)=O)CCC3)=O)=O)=O)=O

• Molecular Weight:

  1348.62

• References & Citations:

  [1]Brian Lannutti, et al. Ror1 antibody immunoconjugates. WO2018237335A1.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, stored under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  2259318-46-0