GGGDTDTC-Mc-vc-PAB-MMAE

• UNSPSC Description:

  GGGDTDTC-Mc-vc-PAB-MMAE is a Drug-Linker Conjugate for ADC, containing a tubulin inhibitor Monomethyl auristatin E (MMAE, HY-15162)[1].

• Target Antigen:

  Drug-Linker Conjugates for ADC; Microtubule/Tubulin

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/gggdtdtc-mc-vc-pab-mmae.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N2[C@@]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C3=CC=CC=C3)=O)([H])CCC2)=O)C)=O)=O)=O)C=C1)=O)=O)NC(CCCCCN4C(C(SC[C@@H](C(N)=O)NC([C@H]([C@H](O)C)NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CC(O)=O)NC(CNC(CNC(CN)=O)=O)=O)=O)=O)=O)=O)CC4=O)=O)=O

• Molecular Weight:

  2040.34

• References & Citations:

  [1]Zhao YJ, et al. Nanobody drug conjugate with high activity and application of GALA polypeptide in antibody drug conjugate. China, CN112807444 A. 2021-05-18.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported