TED-347

CAT: 0804-HY-125269-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-125269-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 μM for TEAD4 Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central pocket of TEAD4 with a Ki of 10.3 μM. TED-347 blocks TEAD transcriptional activity and has antitumor activity[1].
CAS Number
[2378626-29-8]
UNSPSC
12352005
Hazard Statement
H302, H314
Target
YAP
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ted-347.html
Purity
98.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CC=C1NC2=CC=CC(C(F)(F)F)=C2)CCl
Molecular Formula
C15H11ClF3NO
Molecular Weight
313.70
Precautions
H302, H314
References & Citations
[1]Khuchtumur Bum-Erdene, et al. Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction. Cell Chem Biol. 2019 Mar 21;26 (3) :378-389.e13.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
YAP/TAZ-TEAD

Related Products

CatalogName
HY-126233-01PAT-347
HY-113693ONO-RS-347
HY-W953455CRBN ligand-347
HY-RI04371A-01Rno-miR-347 antagomir
HY-R04371-01Rno-miR-347 mimic
HY-RI04371-01Rno-miR-347 inhibitor
HY-R04371A-01Rno-miR-347 agomir
HY-101051-012-TEDC
HY-131292Ro-65-3479
HY-R03073-01Mmu-miR-3474 mimic

Alternative Products

CatalogName
C13811-01TED-347
MN 745120.5Protino Ni-TED
E235-423-13Magose Ni-TED

Popular Products