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Arundic Acid

CAT: 0804-HY-107661-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-107661-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Arundic acid (ONO-2506) is an astrocyte-modulating agent, which delays the expansion of cerebral infarcts by modulating the activation of astrocytes through inhibition of S-100β synthesis. Arundic acid also increases the expression level of EAAT1 by activating the Akt, ERK, and NF-κB signaling pathways, which has the potential to eliminate excess glutamate and inhibit excitotoxic brain damage or death. Arundic acid has the potential for stroke and Alzheimer’s disease research[1][2][3].
CAS Number
185517-21-9
Product Name Alternative
ONO-2506; (R) -2-Propyloctanoic acid
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/arundic-acid.html
Purity
98.0
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
CCCCCC[C@H](C(O)=O)CCC
Molecular Formula
C11H22O2
Molecular Weight
186.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Tomoyuki Hasegawa, et al. Process Development of ONO-2506: A Therapeutic Agent for Stroke and Alzheimer's Disease. Org. Process Res. Dev.200372168-171.|[2]Kato H, et al. Arundic acid, an astrocyte-modulating agent, protects dopaminergic neurons against MPTPneurotoxicity in mice. Brain Res. 2004 Dec 24;1030 (1) :66-73.|[3]Karki P, et al. Arundic Acid Increases Expression and Function of Astrocytic Glutamate Transporter EAAT1 Via the ERK, Akt, and NF-κB Pathways. Mol Neurobiol. 2018 Jun;55 (6) :5031-5046.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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Alternative Products

CatalogName
MBS3613501-01Arundic Acid
FA17995-01R- (-) -Arundic acid
sc-391792S- (+) -Arundic Acid
TRC-A779500-50MGR-(-)-Arundic Acid
TRC-A779510-5MGS-(+)-Arundic Acid
WZB81650-01R- (-) -Arundic acid-d3
464929-01S- (+) -Arundic Acid Methyl Ester
464927-01S- (+) -Arundic Acid Ethyl Ester
463414-01R- (-) -Arundic Acid Methyl Ester
463412-01R- (-) -Arundic Acid Ethyl Ester

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