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Arundic Acid

CAT: 0804-HY-107661-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-107661-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Arundic acid (ONO-2506) is an astrocyte-modulating agent, which delays the expansion of cerebral infarcts by modulating the activation of astrocytes through inhibition of S-100β synthesis. Arundic acid also increases the expression level of EAAT1 by activating the Akt, ERK, and NF-κB signaling pathways, which has the potential to eliminate excess glutamate and inhibit excitotoxic brain damage or death. Arundic acid has the potential for stroke and Alzheimer’s disease research[1][2][3].
CAS Number
185517-21-9
Product Name Alternative
ONO-2506; (R) -2-Propyloctanoic acid
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/arundic-acid.html
Purity
98.0
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
CCCCCC[C@H](C(O)=O)CCC
Molecular Formula
C11H22O2
Molecular Weight
186.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Tomoyuki Hasegawa, et al. Process Development of ONO-2506: A Therapeutic Agent for Stroke and Alzheimer's Disease. Org. Process Res. Dev.200372168-171.|[2]Kato H, et al. Arundic acid, an astrocyte-modulating agent, protects dopaminergic neurons against MPTPneurotoxicity in mice. Brain Res. 2004 Dec 24;1030 (1) :66-73.|[3]Karki P, et al. Arundic Acid Increases Expression and Function of Astrocytic Glutamate Transporter EAAT1 Via the ERK, Akt, and NF-κB Pathways. Mol Neurobiol. 2018 Jun;55 (6) :5031-5046.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

Chemical Information

(R)-(-)-2-propyloctanoic acid

Arundic acid has been investigated for the treatment of Amyotrophic Lateral Sclerosis (ALS).

CAS Number185517-21-9
PubChem CID208925
IUPAC Name(2R)-2-propyloctanoic acid
Molecular FormulaC11H22O2
Molecular Weight186.29
XLogP3.7
Topological Polar Surface Area37.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count8
Heavy Atom Count13
Formal Charge0
Complexity132
SMILES
CCCCCC[C@@H](CCC)C(=O)O
InChI
InChI=1S/C11H22O2/c1-3-5-6-7-9-10(8-4-2)11(12)13/h10H,3-9H2,1-2H3,(H,12,13)/t10-/m1/s1
InChIKey
YCYMCMYLORLIJX-SNVBAGLBSA-N
Chemical Structure
2D Structure
2D structure of (R)-(-)-2-propyloctanoic acid
CAS: 185517-21-9
CID: 208925
Formula: C11H22O2
MW: 186.29
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight186.29
XLogP33.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count8
Exact Mass186.161979940
Monoisotopic Mass186.161979940
Topological Polar Surface Area37.3 Ų
Heavy Atom Count13
Formal Charge0
Complexity132
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
524261Arundic Acid
FA17995-01R- (-) -Arundic acid
TRC-A779500-50MGR-(-)-Arundic Acid
sc-391792S- (+) -Arundic Acid
TRC-A779510-5MGS-(+)-Arundic Acid
WZB81650-01R- (-) -Arundic acid-d3
464929-01S- (+) -Arundic Acid Methyl Ester
464927-01S- (+) -Arundic Acid Ethyl Ester
463414-01R- (-) -Arundic Acid Methyl Ester
463412-01R- (-) -Arundic Acid Ethyl Ester

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