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Enniatin B

CAT: 0804-HY-N3806Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N3806Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 113 μM in an enzyme assay using rat liver microsomes[1]. Enniatins B decreases the activation of ERK (p44/p42) [2].
CAS Number
917-13-5
UNSPSC
12352005
Hazard Statement
H301+H311+H331
Target
Acyltransferase; ERK
Type
Natural Products
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/enniatin-b.html
Purity
99.86
Solubility
DMSO : ≥ 10 mg/mL
Smiles
CC([C@](O1)([H])C(N([C@H](C(O[C@@H](C(N([C@](C(C)C)([H])C(O[C@H](C(C)C)C(N(C)[C@@H](C(C)C)C1=O)=O)=O)C)=O)C(C)C)=O)C(C)C)C)=O)C
Molecular Formula
C33H57N3O9
Molecular Weight
639.82
Precautions
H301+H311+H331
References & Citations
[1]Tomoda H, et al. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J Antibiot (Tokyo) . 1992 Oct;45 (10) :1626-32.|[2]Wätjen W, et al. Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol Nutr Food Res. 2009 Apr;53 (4) :431-40.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
ACAT; ERK

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