MPEP

CAT: 0804-HY-14609A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-14609A-01Size:5 mg
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Description
MPEP is a potent, selective, noncompetitive, orally active and systemically active mGlu5 receptor antagonist, with an IC50 of 36 nM for completely inhibiting quisqualate-stimulated phosphoinositide (PI) hydrolysis. MPEP has anxiolytic-or antidepressant-like effects[1][2]. MPEP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
[96206-92-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mpep.html
Purity
99.42
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=NC(C#CC2=CC=CC=C2)=CC=C1
Molecular Formula
C14H11N
Molecular Weight
193.25
Precautions
H302, H315, H319, H335
References & Citations
[1]F Gasparini, et al. 2-Methyl-6- (phenylethynyl) -pyridine (MPEP), a Potent, Selective and Systemically Active mGlu5 Receptor Antagonist. Neuropharmacology. 1999 Oct;38 (10) :1493-503.|[2]E Tatarczyńska, et al. Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist. Br J Pharmacol. 2001 Apr;132 (7) :1423-30.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5
Citation 01
Neurosci Lett. 2025 Mar 15:852:138193.|SSRN. 2025 Aug 27.|bioRxiv. 2024 November 03.|Epilepsy Res. 2021 Sep:175:106677.|Pharmacol Biochem Behav. 2023 Jun:227-228:173588.|SSRN. 2023 Apr 26.

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