MPEP

• Description:

  MPEP is a potent, selective, noncompetitive, orally active and systemically active mGlu5 receptor antagonist, with an IC50 of 36 nM for completely inhibiting quisqualate-stimulated phosphoinositide (PI) hydrolysis. MPEP has anxiolytic-or antidepressant-like effects[1][2]. MPEP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  MGluR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/mpep.html

• Purity:

  99.42

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC1=NC(C#CC2=CC=CC=C2)=CC=C1

• Molecular Formula:

  C14H11N

• Molecular Weight:

  193.25

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]F Gasparini, et al. 2-Methyl-6- (phenylethynyl) -pyridine (MPEP), a Potent, Selective and Systemically Active mGlu5 Receptor Antagonist. Neuropharmacology. 1999 Oct;38 (10) :1493-503.|[2]E Tatarczyńska, et al. Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist. Br J Pharmacol. 2001 Apr;132 (7) :1423-30.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MGluR5

• Citation 01:

  Neurosci Lett. 2025 Mar 15:852:138193.|SSRN. 2025 Aug 27.|bioRxiv. 2024 November 03.|Epilepsy Res. 2021 Sep:175:106677.|Pharmacol Biochem Behav. 2023 Jun:227-228:173588.|SSRN. 2023 Apr 26.

• CAS Number:

  [96206-92-7]