C8-Ceramide

CAT: 0804-HY-108391-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-108391-01Size:5 mg
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Description
C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro[1][2][3][4].
CAS Number
[74713-59-0]
Product Name Alternative
N-Octanoyl-D-erythro-sphingosine
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H332, H335
Target
Apoptosis; Autophagy; PKC
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Epigenetics; TGF-beta/Smad
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/c8-ceramide.html
Purity
98.0
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CCCCCCCC(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)=O
Molecular Formula
C26H51NO3
Molecular Weight
425.69
Precautions
H302, H315, H319, H332, H335
References & Citations
[1]Rebeca López-Marure , et al. Ceramide promotes the death of human cervical tumor cells in the absence of biochemical and morphological markers of apoptosis. Biochem Biophys Res Commun. 2002 May 10;293 (3) :1028-36.|[2]Curtis J. Pritzl, et al. A ceramide analogue stimulates dendritic cells to promote T cell responses upon virus infections. J Immunol. 2015 May 1; 194 (9) : 4339-4349.|[3]Yuli C. Chang, et al. Exogenous C8-Ceramide Induces Apoptosis by Overproduction of ROS and the Switch of Superoxide Dismutases SOD1 to SOD2 in Human Lung Cancer Cells. Int J Mol Sci. 2018 Oct; 19 (10) : 3010.|[4]H W Huang, et al. Ceramides modulate protein kinase C activity and perturb the structure of Phosphatidylcholine/Phosphatidylserine bilayers. Biophys J. 1999 Sep; 77 (3) : 1489-1497.|[5]Lan Weiss, et al. Ceramide contributes to pathogenesis and may be targeted for therapy in VCP inclusion body myopathy. Hum Mol Genet. 2021 Jan 7; ddaa248.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKC

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