C16-Ceramide

• Description:

  C16-Ceramide is a natural small molecule activating p53 through the direct and selective binding[1].

• UNSPSC:

  12352211

• Hazard Statement:

  H315, H319, H335

• Target:

  Apoptosis; Endogenous Metabolite; MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/c16-ceramide.html

• Purity:

  99.0

• Solubility:

  DMF : 20 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : < 1 mg/mL (ultrasonic) |Ethanol : 10 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  CCCCCCCCCCCCCCCC (N[C@@H] (CO) [C@H] (O) /C=C/CCCCCCCCCCCCC) =O

• Molecular Formula:

  C34H67NO3

• Molecular Weight:

  537.90

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Fekry B, et al. C16-ceramide is a natural regulatory ligand of p53 in cellular stress response. Nat Commun. 2018 Oct 8;9 (1) :4149.|[2]Rénert AF, et al. The proapoptotic C16-ceramide-dependent pathway requires the death-promoting factor Btf in colon adenocarcinoma cells. J Proteome Res. 2009 Oct;8 (10) :4810-22.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  24696-26-2