C16-Ceramide

• Description :

  C16-Ceramide is a natural small molecule activating p53 through the direct and selective binding[1].

• UNSPSC :

  12352211

• Hazard Statement :

  H315, H319, H335

• Target :

  Apoptosis; Endogenous Metabolite; MDM-2/p53

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/c16-ceramide.html

• Purity :

  99.0

• Solubility :

  DMF : 20 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : < 1 mg/mL (ultrasonic) |Ethanol : 10 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  CCCCCCCCCCCCCCCC(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)=O

• Molecular Formula :

  C34H67NO3

• Molecular Weight :

  537.90

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Fekry B, et al. C16-ceramide is a natural regulatory ligand of p53 in cellular stress response. Nat Commun. 2018 Oct 8;9 (1) :4149.|[2]Rénert AF, et al. The proapoptotic C16-ceramide-dependent pathway requires the death-promoting factor Btf in colon adenocarcinoma cells. J Proteome Res. 2009 Oct;8 (10) :4810-22.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [24696-26-2]