KN-92 (hydrochloride)

KN-92 (hydrochloride)

• CAS Number: 1431698-47-3
• UNSPSC Description: KN-92 hydrochloride is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 hydrochloride is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93[1][2].
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/KN-92-hydrochloride.html
• Solubility: DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=S(C1=CC=C(OC)C=C1)(NC2=CC=CC=C2CN(C/C=C/C3=CC=C(Cl)C=C3)C)=O.[H]Cl
• Molecular Weight: 493.45
• References & Citations: [1]Smyth JT, et al. Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/calmodulin-dependent protein kinase II antagonism. J Biol Chem. 2002;277(38):35061-35070.|[2]An P, et al. KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro. World J Gastroenterol. 2007;13(9):1445-1448.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported