[6]-Gingerol

• Description :

  [6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.

• Product Name Alternative :

  (S) - (+) -[6]Gingerol

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H315, H319, H335

• Target :

  AMPK; Apoptosis

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Epigenetics; PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/[6]-Gingerol.html

• Concentration :

  10mM

• Purity :

  99.68

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  CCCCC[C@H](O)CC(CCC1=CC=C(O)C(OC)=C1)=O

• Molecular Formula :

  C17H26O4

• Molecular Weight :

  294.39

• Precautions :

  H301, H315, H319, H335

• References & Citations :

  [1]Radhakrishnan EK, et al. [6]-Gingerol induces caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signaling. PLoS One. 2014 Aug 26;9 (8) :e104401.|[2]Chang KW, et al. 6-Gingerol modulates proinflammatory responses in dextran sodium sulfate (DSS) -treated Caco-2 cells and experimental colitis in mice through adenosine monophosphate-activated protein kinase (AMPK) activation. Food Funct. 2015 Oct;6 (10) :3334-41.|[3]Fan J, et al. 6-Gingerol inhibits osteosarcoma cell proliferation through apoptosis and AMPK activation. Tumour Biol. 2015 Feb;36 (2) :1135-41.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  AMPK

• CAS Number :

  [23513-14-6]