Fosfomycin (calcium)

• UNSPSC Description:

  Fosfomycin (MK-0955) calcium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin calcium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[1][2].

• Target Antigen:

  Antibiotic; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Fosfomycin-calcium.html

• Purity:

  98.0

• Solubility:

  DMSO : < 1 mg/mL|H2O : 50 mg/mL (ultrasonic;adjust pH to 2 with HCl)

• Smiles:

  C[C@H]1[C@@H](P([O-])([O-])=O)O1.[Ca+2]

• Molecular Weight:

  176.12

• References & Citations:

  [1]Dijkmans AC, et al. Fosfomycin: Pharmacological, Clinical and Future Perspectives. Antibiotics (Basel). 2017 Oct 31;6(4). pii: E24.|[2]Falagas ME, et al. Fosfomycin. Clin Microbiol Rev. 2016 Apr. 29(2):321-47.|[3]Inouye S, et al. Protective effect of fosfomycin on the experimental nephrotoxicity induced by dibekacin. J Pharmacobiodyn. 1982 Sep. 5(9):659-69.|[4]Inouye S, et al. Mode of protective action of fosfomycin against dibekacin-induced nephrotoxicity in the dehydrated rats. J Pharmacobiodyn. 1982 Dec. 5(12):941-50. Front Cell Infect Microbiol. 2019 Jul 15;9:253.|J Med Microbiol. 2019 Mar;68(3):493-502.|ACS Infect Dis. 2024 Jul 27.|Antibiotics (Basel). 2021 Sep 14;10(9):1110.|bioRxiv. 2024 May 10.|Nat Commun. 2022 Mar 2;13(1):1116.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched

• CAS Number:

  26016-98-8