Fosfomycin (calcium)

Fosfomycin (calcium)

• CAS Number: 26016-98-8
• UNSPSC Description: Fosfomycin (MK-0955) calcium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin calcium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[1][2].
• Target Antigen: Antibiotic; Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Infection; Cancer
• Assay Protocol: https://www.medchemexpress.com/Fosfomycin-calcium.html
• Purity: 98.0
• Solubility: DMSO : < 1 mg/mL|H2O : 50 mg/mL (ultrasonic;adjust pH to 2 with HCl)
• Smiles: C[C@H]1[C@@H](P([O-])([O-])=O)O1.[Ca+2]
• Molecular Weight: 176.12
• References & Citations: [1]Dijkmans AC, et al. Fosfomycin: Pharmacological, Clinical and Future Perspectives. Antibiotics (Basel). 2017 Oct 31;6(4). pii: E24.|[2]Falagas ME, et al. Fosfomycin. Clin Microbiol Rev. 2016 Apr. 29(2):321-47.|[3]Inouye S, et al. Protective effect of fosfomycin on the experimental nephrotoxicity induced by dibekacin. J Pharmacobiodyn. 1982 Sep. 5(9):659-69.|[4]Inouye S, et al. Mode of protective action of fosfomycin against dibekacin-induced nephrotoxicity in the dehydrated rats. J Pharmacobiodyn. 1982 Dec. 5(12):941-50. Front Cell Infect Microbiol. 2019 Jul 15;9:253.|J Med Microbiol. 2019 Mar;68(3):493-502.|ACS Infect Dis. 2024 Jul 27.|Antibiotics (Basel). 2021 Sep 14;10(9):1110.|bioRxiv. 2024 May 10.|Nat Commun. 2022 Mar 2;13(1):1116.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: Launched