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Fosfomycin (calcium)

CAT: 0804-HY-B1075Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1075Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fosfomycin (MK-0955) calcium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin calcium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[1][2].
CAS Number
26016-98-8
Product Name Alternative
MK-​0955 (calcium)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/Fosfomycin-calcium.html
Purity
98.0
Solubility
H2O : 50 mg/mL (ultrasonic; adjust pH to 2 with HCl)
Smiles
C[C@H]1[C@@H](P([O-])([O-])=O)O1.[Ca+2]
Molecular Formula
C3H5CaO4P
Molecular Weight
176.12
Precautions
H302, H315, H319, H335
References & Citations
[1]Dijkmans AC, et al. Fosfomycin: Pharmacological, Clinical and Future Perspectives. Antibiotics (Basel) . 2017 Oct 31;6 (4) . pii: E24.|[2]Falagas ME, et al. Fosfomycin. Clin Microbiol Rev. 2016 Apr. 29 (2) :321-47.|[3]Inouye S, et al. Protective effect of fosfomycin on the experimental nephrotoxicity induced by dibekacin. J Pharmacobiodyn. 1982 Sep. 5 (9) :659-69.|[4]Inouye S, et al. Mode of protective action of fosfomycin against dibekacin-induced nephrotoxicity in the dehydrated rats. J Pharmacobiodyn. 1982 Dec. 5 (12) :941-50.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Front Cell Infect Microbiol. 2019 Jul 15:9:253.|J Med Microbiol. 2019 Mar;68 (3) :493-502.|ACS Infect Dis. 2024 Aug 9;10 (8) :2961-2977.|Antibiotics (Basel) . 2021 Sep 14;10 (9) :1110.|bioRxiv. 2024 May 10.|bioRxiv. 2025 January 19.|J Antibiot (Tokyo) . 2025 Mar;78 (4) :265-273.|MedComm (2020) . 2025 Jan 8;6 (1) :e70046.|Molecules. 2025 Mar 9;30 (6) :1224.|Nat Commun. 2022 Mar 2;13 (1) :1116.|Infect Genet Evol. 2025 Sep:133:105780.|Microb Pathog. 2025 Oct 25.|Microbiol Spectr. 2025 Sep 2;13 (9) :e0152125.

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