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CBL0137 (hydrochloride)

CAT: 0804-HY-18935A-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18935A-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CBL0137 hydrochloride is an inhibitor of the histone chaperone, FACT. CBL0137 hydrochloride can also activate p53 and inhibits NF-κB with EC50s of 0.37 and 0.47 μM, respectively.
CAS Number
1197397-89-9
Product Name Alternative
Curaxin-137 (hydrochloride) ; CBL-C137 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MDM-2/p53; NF-κB
Type
Reference compound
Related Pathways
Apoptosis; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CBL0137_hydrochloride.html
Purity
99.72
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 10 mg/mL (ultrasonic)
Smiles
CC(NCCN1C2=C(C3=C1C=CC(C(C)=O)=C3)C=C(C(C)=O)C=C2)C.[H]Cl
Molecular Formula
C21H25ClN2O2
Molecular Weight
372.89
Precautions
H302, H315, H319, H335
References & Citations
[1]Burkhart C, et al. Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer. Oncotarget. 2014 Nov 30;5 (22) :11038-53.|[2]Gasparian AV, et al. Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT. Sci Transl Med. 2011 Aug 10;3 (95) :95ra74.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
NF-κB
Citation 01
Adv Mater. 2024 Jul;36 (29) :e2313991.|Cancer Res. 2021 Jun 1;81 (11) :3105-3120.|Cell Death Dis. 2020 Dec 2;11 (12) :1029.|Cell. 2024 Dec 26;187 (26) :7533-7550.e23.|Mol Med Rep. 2024 Nov;30 (5) :209.|Oncogene. 2023 Jan;42 (1) :11-25.|Cell Death Dis. 2024 Oct 27;15 (10) :779.|Eur J Med Chem. 2024 Apr 15:270:116377.|J Neuroinflammation. 2025 Oct 27;22 (1) :243.|Nano Today. 2025 Oct.

Chemical Information

Cblc137

a FACT histone chaperone inhibitor with antineoplastic activity; structure in first source

CAS Number1197397-89-9
PubChem CID44519123
IUPAC Name1-[6-acetyl-9-[2-(propan-2-ylamino)ethyl]carbazol-3-yl]ethanone;hydrochloride
Molecular FormulaC21H25ClN2O2
Molecular Weight372.9
Topological Polar Surface Area51.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Heavy Atom Count26
Formal Charge0
Complexity466
SMILES
CC(C)NCCN1C2=C(C=C(C=C2)C(=O)C)C3=C1C=CC(=C3)C(=O)C.Cl
InChI
InChI=1S/C21H24N2O2.ClH/c1-13(2)22-9-10-23-20-7-5-16(14(3)24)11-18(20)19-12-17(15(4)25)6-8-21(19)23;/h5-8,11-13,22H,9-10H2,1-4H3;1H
InChIKey
IXRKBBVMDMKAEB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cblc137
CAS: 1197397-89-9
CID: 44519123
Formula: C21H25ClN2O2
MW: 372.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight372.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Exact Mass372.1604557
Monoisotopic Mass372.1604557
Topological Polar Surface Area51.1 Ų
Heavy Atom Count26
Formal Charge0
Complexity466
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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