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SBP-0636457

CAT: 0804-HY-125378-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-125378-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an IAP antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins, with a Ki of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers[1][2].
CAS Number
1422180-49-1
Product Name Alternative
SBI-0636457; SB1-0636457
UNSPSC
12352005
Target
IAP
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sbp-0636457.html
Purity
98.42
Solubility
DMSO : 45.71 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C([C@@H]1C(C)(C)C[C@](N21)([H])OCC[C@H](NC([C@@H](NC)C)=O)C2=O)N[C@@H]3CCCC4=C3C=CC=C4
Molecular Formula
C25H36N4O4
Molecular Weight
456.58
References & Citations
[1]Finlay D, et, al. Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs. Mol Cancer Ther. 2014 Jan; 13 (1) : 5-15.|[2]Finlay D, et, al. Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins. F1000Res. 2017 Apr 27; 6:587.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
XIAP

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