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SBP-1750

CAT: 0013-GTR19272709-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19272709-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SBP-1750 is a potent, orally active autophagy inhibitor with a dual mechanism of action. It functions as a kinase inhibitor, strongly suppressing ULK1 (IC50 = 8 nM) and ULK2 (IC50 = 50 nM) activity, while simultaneously inducing the degradation of ATG13 (EC50 = 114 nM) . This dual-targeting approach effectively blocks autophagic flux and induces cell death, exhibiting significant efficacy particularly against KRAS-mutant cancers such as pancreatic and lung cancers.
CAS Number
1884219-70-8
Purity
99.59% (May vary between batches)
Smiles
O=C (NC) C=1C=CC=CC1NC2=NC (=NC=C2Cl) NC3=CC (OC) =C (OC) C (OC) =C3
Molecular Formula
C21H22ClN5O4
Molecular Weight
443.88
Storage Conditions
-20°C
Notes
For research use only.

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