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KLF10-IN-1

CAT: 0804-HY-W181026-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W181026-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KLF10-IN-1 (#48-15) is a KLF10 inhibitor with an IC50 value of 40 μM for KLF10 reporter gene. KLF10-IN-1 can inhibit KLF10-DNA binding and transcriptional activity, block the conversion of CD4+CD25 T cells to CD4+CD25+T regulatory cells, and inhibit the expression of KLF10 target genes. KLF10-IN-1 can be used as a useful mechanistic probe to study KLF10-mediated effects and T regulatory cell biology[1].
CAS Number
1197834-98-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Fluorescent Dye
Type
Reference compound
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/klf10-in-1.html
Purity
99.84
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(OCC(C1=CC=C(OC)C=C1)=O)C2=CC(C)=CC=C2O
Molecular Formula
C17H16O5
Molecular Weight
300.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Khedkar SA, et al. Discovery of small molecule inhibitors to Krüppel-like factor 10 (KLF10) : implications for modulation of T regulatory cell differentiation. J Med Chem. 2015;58 (3) :1466-1478.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

2-(4-Methoxyphenyl)-2-oxoethyl 2-hydroxy-5-methylbenzoate
CAS Number1197834-98-2
PubChem CID8958571
IUPAC Name[2-(4-methoxyphenyl)-2-oxoethyl] 2-hydroxy-5-methylbenzoate
Molecular FormulaC17H16O5
Molecular Weight300.30
XLogP3.7
Topological Polar Surface Area72.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count22
Formal Charge0
Complexity387
SMILES
CC1=CC(=C(C=C1)O)C(=O)OCC(=O)C2=CC=C(C=C2)OC
InChI
InChI=1S/C17H16O5/c1-11-3-8-15(18)14(9-11)17(20)22-10-16(19)12-4-6-13(21-2)7-5-12/h3-9,18H,10H2,1-2H3
InChIKey
BLBCTMGFGIFKTC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(4-Methoxyphenyl)-2-oxoethyl 2-hydroxy-5-methylbenzoate
CAS: 1197834-98-2
CID: 8958571
Formula: C17H16O5
MW: 300.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight300.30
XLogP33.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass300.09977361
Monoisotopic Mass300.09977361
Topological Polar Surface Area72.8 Ų
Heavy Atom Count22
Formal Charge0
Complexity387
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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