Nrf2 Recombinant Rabbit Monoclonal Antibody [JE30-14]

Nrf2 Recombinant Rabbit Monoclonal Antibody [JE30-14]

• Description: Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine zipper (bZIP) protein that may regulate the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation, according to preliminary research.[6] In vitro, NRF2 binds to antioxidant response elements (AREs) in the promoter regions of genes encoding cytoprotective proteins. NRF2 induces the expression of heme oxygenase 1 in vitro leading to an increase in phase II enzymes. NRF2 also inhibits the NLRP3 inflammasome. NRF2 appears to participate in a complex regulatory network and performs a pleiotropic role in the regulation of metabolism, inflammation, autophagy, proteostasis, mitochondrial physiology, and immune responses.
• Product Name Alternative: erythroid derived 2 antibody HEBP1 antibody like 2 antibody NF E2 related factor 2 antibody NF-E2-related factor 2 antibody NF2L2_HUMAN antibody NFE2 related factor 2 antibody NFE2-related factor 2 antibody Nfe2l2 antibody Nrf 2 antibody NRF2 antibody Nuclear factor (erythroid derived 2) like 2 antibody Nuclear factor antibody nuclear factor erythroid 2 like 2 antibody Nuclear factor erythroid 2 related factor 2 antibody Nuclear factor erythroid 2-related factor 2 antibody Nuclear factor erythroid derived 2 like 2 antibody
• Abbreviation: NF-E2-related factor 2, NFE2-related factor 2, NFE2L2
• CAS Number: 9000-83-3
• Swiss Prot: Q16236 Human, Q60795 Mouse
• Cellular Locus: Cytoplasm, Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Synthetic peptide within Human Nrf2 aa 550-605.
• Isotype: IgG
• Clone: JE30-14
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell
• Positive Control: HeLa whole cell lysate, HeLa treated with 2μM MG-132 for 18 hours whole cell lysate, HCT 116 whole cell lysate, HCT 116 treated with 25μM MG-132 for 4 hours whole cell lysate, NIH/3T3 treated with 10μM MG-132 for 8 hours cell lysate, HCT 116.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IF-Cell: 1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 68 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes