Chlormethine (hydrochloride)
CAT:
804-HY-B1253-01
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Chlormethine (hydrochloride)
- CAS Number: 55-86-7
- UNSPSC Description: Chlormethine hydrochloride is a foaming agent that causes necrotic and irritating damage to mucous membranes. Used as an antitumor agent in Hodgkin's disease and lymphoma.
- Target Antigen: Others
- Type: Reference compound
- Related Pathways: Others
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/Chlormethine-hydrochloride.html
- Purity: 98.0
- Solubility: DMSO : 250 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
- Smiles: ClCCN(CCCl)C.[H]Cl
- Molecular Weight: 192.51
- References & Citations: [1]Cao Z, et al. Effect of brentuximab vedotin combined with chlormethine hydrochloride on the treatment of 6 patients with relapsed and refractory Hodgkin lymphoma. Zhonghua Xue Ye Xue Za Zhi. 2015 Jul 14;36(7):575-577.|[2]Yuan Yang, et al. Chlormethine Hydrochloride is Not Inferior to Tacrolimus in Treating Steroid-Resistant Nephrotic Syndrome. Kidney Blood Press Res. 2018;43(1):68-79.|[3]Liren Tang, et al. Topical mechlorethamine restores autoimmune-arrested follicular activity in mice with an alopecia areata-like disease by targeting infiltrated lymphocytes. J Invest Dermatol. 2003 Mar;120(3):400-6.|[4]K Bryniarski, et al. The in vivo and in vitro effects of an alkylating agent, mechlorethamine, on IL-6 production in mice and the role of macrophages. Immunopharmacology. 1996 Sep;34(2-3):73-8.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Launched