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Lucanthone (hydrochloride)

CAT: 0804-HY-B2098ASize: 1 EachDry Ice: NoHazardous: No
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Description
Lucanthone hydrochloride is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1) .
CAS Number
548-57-2
UNSPSC
12352005
Target
Autophagy; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lucanthone-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(C(C)=CC=C2NCCN(CC)CC)SC3=C1C=CC=C3.Cl
Molecular Formula
C20H25ClN2OS
Molecular Weight
376.94
References & Citations
[1]Chowdhury SM, et al. Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme. Nanomedicine. 2015 Jan;11 (1) :109-18.|[2]Carew JS, et al. Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286 (8) :6602-13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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