Lucanthone

• Description :

  Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1) .

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Autophagy; Parasite

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Autophagy

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Lucanthone.html

• Concentration :

  10mM

• Purity :

  99.63

• Solubility :

  DMSO : 25 mg/mL (ultrasonic)

• Smiles :

  O=C1C2=C(SC3=C1C=CC=C3)C(C)=CC=C2NCCN(CC)CC

• Molecular Formula :

  C20H24N2OS

• Molecular Weight :

  340.48

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Chowdhury SM, et al. Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme. Nanomedicine. 2015 Jan;11 (1) :109-18.|[2]Carew JS, et al. Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286 (8) :6602-13.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [479-50-5]