Lucanthone

• UNSPSC Description:

  Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).

• Target Antigen:

  Autophagy; Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Autophagy

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Lucanthone.html

• Purity:

  99.75

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  O=C1C2=C(SC3=C1C=CC=C3)C(C)=CC=C2NCCN(CC)CC

• Molecular Weight:

  340.48

• References & Citations:

  [1]Chowdhury SM, et al. Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme. Nanomedicine. 2015 Jan;11(1):109-18.|[2]Carew JS, et al. Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  479-50-5