Cdc7-IN-1

Cdc7-IN-1

• CAS Number: 1402055-25-7
• UNSPSC Description: Cdc7-IN-1 (Compound 13) is a highly potent, selective and ATP competitive inhibitor of Cdc7 kinase, with an IC50 value of 0.6 nM at 1 mM ATP and with slow off-rate characteristics. Cdc7-IN-1 potently inhibits Cdc7 activity in cancer cells, and effectively induces cell death[1].
• Target Antigen: CDK
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cdc7-in-1.html
• Purity: 99.77
• Solubility: DMSO : 5.2 mg/mL (ultrasonic)
• Smiles: O=C1C(C(OCC)=O)=C(NC2=C(Cl)C=CC=C2)O/C1=C\C3=CNC4=C3C=CC=N4
• Molecular Weight: 409.82
• References & Citations: [1]Irie T, et al. Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors. Eur J Med Chem. 2017 Apr 21;130:406-418.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported