CFTR corrector 4

CFTR corrector 4

• CAS Number: 1918142-34-3
• UNSPSC Description: CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis[1].
• Target Antigen: CFTR
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/cftr-corrector-4.html
• Smiles: O=C(C1(C2=CC=C(OC(F)(F)O3)C3=C2)CC1)N[C@@H]4C[C@H](C5=CC=C(OC)C(OC)=C5)OC6=CC(OC)=CC=C46
• Molecular Weight: 539.52
• References & Citations: [1]Wang X, et al. Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis.
• Shipping Conditions: Room Temperature