CFTR corrector 8

CFTR corrector 8

• CAS Number: 1918142-35-4
• UNSPSC Description: CFTR corrector 8 is a potent CFTR modulator. CFTR can be used in the research of cystic fibrosis[1].
• Target Antigen: CFTR
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/cftr-corrector-8.html
• Solubility: DMSO : 110 mg/mL (ultrasonic)
• Smiles: COC(C=C1[C@H](C2)OC3=CC(OC)=CC=C3[C@H]2NC(C4(C5=CC=C(OC(F)(O6)F)C6=C5)CC4)=O)=C(C=C1)OC
• Molecular Weight: 539.52
• References & Citations: [1]Wang X, et al. Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis. J Med Chem. 2018 Feb 22;61(4):1436-1449.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported