STAT3-IN-20

STAT3-IN-20

• CAS Number: 2768427-54-7
• UNSPSC Description: STAT3-IN-20 (Compound 40) is a selective STAT3 inhibitor (IC50: 0.65 μM). STAT3-IN-20 binds the SH2 domain to inhibit STAT3 phosphorylation, translocation, and downstream gene transcription. STAT3-IN-20 exhibits antiproliferative activities against STAT3-overactivated DU145 and MDA-MB-231 cancer cells (IC50: 2.97 μM and 3.26 μM respectively). STAT3-IN-20 induces cell cycle arrest and apoptosis[1].
• Target Antigen: STAT
• Type: Reference compound
• Related Pathways: JAK/STAT Signaling;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/stat3-in-20.html
• Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 80°C)
• Smiles: FC1=CC=C(C2=NC3=CC(NC4=NN=C(S4)C5=CC=C(C=C5)C(F)(F)F)=C(C=C3N2C6CC6)N7CCN(CC7)C)C=C1
• Molecular Weight: 593.64
• References & Citations: [1]Wang R, et al. Discovery, Optimization, and Evaluation of Novel N-(Benzimidazol-5-yl)-1,3,4-thiadiazol-2-amine Analogues as Potent STAT3 Inhibitors for Cancer Treatment. J Med Chem. 2023 Aug 18.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported