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1,3-Butanediol

CAT: 0804-HY-77490A-01Size: 25 gDry Ice: NoHazardous: No
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CAT#:0804-HY-77490A-01Size:25 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
1,3-Butanediol, an orally active ethanol dimer providing a source of calories for human nutrition. 1,3-Butanediol administeration can stimulate the biosynthesis of the ketone body, β-hydroxybutyrate (βHB) . 1,3-Butanediol has cerebral protective and hypoglycaemic effect[1][2][3].
CAS Number
107-88-0
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/1-3-butanediol.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 500 mg/mL
Smiles
CC(O)CCO
Molecular Formula
C4H10O2
Molecular Weight
90.12
Precautions
H302, H315, H319, H335
References & Citations
[2]R B Tobin, et al. Nutritional and metabolic studies in humans with 1,3-butanediol. Fed Proc. 1975 Nov;34 (12) :2171-6.|[3]McCarthy CG, et al. Physiologic, Metabolic, and Toxicologic Profile of 1,3-Butanediol. J Pharmacol Exp Ther. 2021 Nov;379 (3) :245-252.|[4]McCarthy CG, et al. Low-dose 1,3-butanediol reverses age-associated vascular dysfunction independent of ketone body β-hydroxybutyrate. Am J Physiol Heart Circ Physiol. 2022 Mar 1;322 (3) :H466-H473. |[5]Gueldry S, et al. Beneficial effect of 1,3-butanediol on cerebral energy metabolism and edema following brain embolization in rats. Stroke. 1990 Oct;21 (10) :1458-63.|[1]C Marie, et al. Protective action of 1,3-butanediol in cerebral ischemia. A neurologic, histologic, and metabolic study. J Cereb Blood Flow Metab. 1987 Dec;7 (6) :794-800.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2