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Dibenzoylmethane (Standard)

CAT: 0804-HY-W009731R-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W009731R-01Size:25 mg
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Description
Dibenzoylmethane (Standard) is the analytical standard of Dibenzoylmethane. This product is intended for research and analytical applications. Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2[1].
CAS Number
120-46-7
UNSPSC
12352005
Target
Keap1-Nrf2; Reference Standards
Type
Reference Standards
Related Pathways
NF-κB; Others
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/dibenzoylmethane-standard.html
Purity
90.000000
Smiles
O=C(C1=CC=CC=C1)CC(C2=CC=CC=C2)=O
Molecular Formula
C15H12O2
Molecular Weight
224.26
References & Citations
[1]Mingnan Cao, et al. Dibenzoylmethane Protects Against CCl4-Induced Acute Liver Injury by Activating Nrf2 via JNK, AMPK, and Calcium Signaling. AAPS J. 2017 Nov;19 (6) :1703-1714.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference Standards

Chemical Information

Dibenzoylmethane

Dibenzoylmethane is a beta-diketone that is acetylacetone (acac) in which both methyl groups have been replaced by phenyl groups. It is a minor constituent of the root extract of licorice (Glycyrrhiza glabra) and exhibits antimutagenic and anticancer effects. It has a role as a metabolite, an antineoplastic agent and an antimutagen. It is a beta-diketone and an aromatic ketone.

CAS Number120-46-7
PubChem CID8433
IUPAC Name1,3-diphenylpropane-1,3-dione
Molecular FormulaC15H12O2
Molecular Weight224.25
XLogP3.1
Topological Polar Surface Area34.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Heavy Atom Count17
Formal Charge0
Complexity243
SMILES
C1=CC=C(C=C1)C(=O)CC(=O)C2=CC=CC=C2
InChI
InChI=1S/C15H12O2/c16-14(12-7-3-1-4-8-12)11-15(17)13-9-5-2-6-10-13/h1-10H,11H2
InChIKey
NZZIMKJIVMHWJC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Dibenzoylmethane
CAS: 120-46-7
CID: 8433
Formula: C15H12O2
MW: 224.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight224.25
XLogP33.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass224.083729621
Monoisotopic Mass224.083729621
Topological Polar Surface Area34.1 Ų
Heavy Atom Count17
Formal Charge0
Complexity243
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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