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Rabeprazole Sulfide (Standard)

CAT: 0804-HY-W003467R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W003467R-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rabeprazole Sulfide (Standard) is the analytical standard of Rabeprazole Sulfide. This product is intended for research and analytical applications. Rabeprazole Sulfide is an active metabolite of Rabeprazole. Rabeprazole is a proton pump inhibitor that suppresses gastric acid secretion through an interaction with (H+/K+) -ATPase in gastric parietal cells. Rabeprazole markedly inhibits the motility of H. pylori. Rabeprazole has the potential for various peptic diseases treatment[1][2].
CAS Number
117977-21-6
UNSPSC
12352005
Target
Bacterial; Proton Pump; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Others
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rabeprazole-sulfide-standard.html
Smiles
CC1=C(OCCCOC)C=CN=C1CSC2=NC3=CC=CC=C3N2
Molecular Formula
C18H21N3O2S
Molecular Weight
343.44
References & Citations
[1]Uno T, et al. Determination of rabeprazole and its active metabolite, rabeprazole thioether in human plasma by column-switching high-performance liquid chromatography and its application to pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 25;824 (1-2) :238-43.|[2]Tsutsui N, et al. A novel action of the proton pump inhibitor rabeprazole and its thioether derivative against the motility of Helicobacter pylori. Antimicrob Agents Chemother. 2000 Nov;44 (11) :3069-73.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
No Development Reported

Chemical Information

Rabeprazole-thioether

structure in first source

CAS Number117977-21-6
PubChem CID9949996
IUPAC Name2-[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methylsulfanyl]-1H-benzimidazole
Molecular FormulaC18H21N3O2S
Molecular Weight343.4
XLogP3.3
Topological Polar Surface Area85.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Heavy Atom Count24
Formal Charge0
Complexity374
SMILES
CC1=C(C=CN=C1CSC2=NC3=CC=CC=C3N2)OCCCOC
InChI
InChI=1S/C18H21N3O2S/c1-13-16(19-9-8-17(13)23-11-5-10-22-2)12-24-18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,20,21)
InChIKey
BSXAHDOWMOSVAP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Rabeprazole-thioether
CAS: 117977-21-6
CID: 9949996
Formula: C18H21N3O2S
MW: 343.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight343.4
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Exact Mass343.13544809
Monoisotopic Mass343.13544809
Topological Polar Surface Area85.3 Ų
Heavy Atom Count24
Formal Charge0
Complexity374
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

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