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Camostat (mesylate)

CAT: 0804-HY-13512-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13512-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2, shows antiviral activity against SARS-CoV-2. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase[1][2][3].
CAS Number
59721-29-8
Product Name Alternative
Camostat mesilate; FOY305; FOY-S980
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H400
Target
SARS-CoV; Ser/Thr Protease
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Camostat-mesylate.html
Purity
99.94
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL
Smiles
O=C(OCC(N(C)C)=O)CC1=CC=C(OC(C2=CC=C(NC(N)=N)C=C2)=O)C=C1.CS(=O)(O)=O
Molecular Formula
C21H26N4O8S
Molecular Weight
494.52
Precautions
H315, H319, H335, H400
References & Citations
[1]Gibo J, et al. Camostat mesilate attenuates pancreatic fibrosis via inhibition of monocytes and pancreatic stellate cells activity. Lab Invest. 2005;85 (1) :75‐89.|[2]Uno Y. Camostat mesilate therapy for COVID-19 [published online ahead of print, 2020 Apr 29]. Intern Emerg Med. 2020;1‐2.|[3]Coote K, et al. Camostat attenuates airway epithelial sodium channel function in vivo through the inhibition of a channel-activating protease. J Pharmacol Exp Ther. 2009;329 (2) :764‐774.|[4]Zhou Y, Vedantham P, Lu K, et al. Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Res. 2015;116:76‐84.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Am J Physiol Renal Physiol. 2024 Aug 1;327 (2) :F265-F276.|Antiviral Res. 2023 Jun:214:105606.|Biochem Pharmacol. 2023 Jul:213:115617.|Biosaf Health. 2022 Feb;4 (1) :38-44.|Cell Discov. 2021 Dec 14;7 (1) :119.|Cell Prolif. 2025 May 15:e70060.|Cell Rep Med. 2022 Sep 20;3 (9) :100743.|Cell. 2023 Feb 16;186 (4) :850-863.e16.|EBioMedicine. 2023 Sep:95:104753.|Emerg Microbes Infect. 2022 Dec;11 (1) :2275-2287.|Eur J Med Chem. 2021 Nov 15:224:113683.|Eur J Pharmacol. 2022 Mar 15:919:174795.|Eur J Pharmacol. 2023 Jan 5:938:175394.|Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Transmissores de Hematozoários. 2020 Sep.|J Virol. 2023 May 31;97 (5) :e0032423.|J Virol. 2025 Nov 18:e0127425.|mBio. 2022 Dec 20;13 (6) :e0256622.|Nat Chem Biol. 2022 Sep;18 (9) :963-971.|Nat Commun. 2022 Jul 26;13 (1) :4331.|Nat Commun. 2022 Mar 17;13 (1) :1444.|Nat Commun. 2024 Jul 3;15 (1) :5606.|Nat Commun. 2024 Oct 9;15 (1) :8728.|Nat Commun. 2025 Jul 7;16 (1) :6241.|Nat Microbiol. 2024 Sep;9 (9) :2383-2394.|Nat Microbiol. 2025 Oct 30, 10 (11) :2860-2874.|Nature. 2022 Mar;603 (7902) :693-699.|Nucleic Acids Res. 2021 Jan 8;49 (D1) :D1113-D1121.|Proc Natl Acad Sci U S A. 2022 Jan 25;119 (4) :e2117576119.|Res Sq. 2023 Sep 11:rs.3.rs-3220157.|Res Sq. 2024 Nov 21.|Research Square Preprint. 2022 Jan.|Sci Adv. 2023 Jan 20;9 (3) :eadd3867.|Sci China Life Sci. 2025 Oct 24.|Sci Signal. 2024 Aug 20;17 (850) :eadn3785.|Signal Transduct Target Ther. 2022 Mar 11;7 (1) :83.|SSRN. 2020 Jun.|SSRN. 2024 Jan 26.|SSRN. 2024 Jul 11.|Utrecht University. CENTER FOR CELL IMAGING. 2022 Jul.|Viruses. 2022 Feb 8;14 (2) :353.|J Virol. 2025 Aug 11:e0105525.|PLoS Pathog. 2025 Oct 14;21 (10) :e1013593.

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