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MAPK14 antibody

CAT: 0710-FNab10331Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab10331Size:100 µg
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Background
MAPK14 (mitogen-activated protein kinase 14) is also named as SAPK2A, p38MAPK, CSBP1, RK, p38, EXIP, Mxi2, CSBP2, PRKM14, PRKM15, CSPB1, p38ALPHA and belongs to the MAP kinase subfamily. MAPK14-signaling is a central pathway for the integration of instructive signals in dendritic cells for T (H) 17 differentiation and inflammation (PMID:22231518) . It plays an important role in the regulation of hematopoietic stem cellself-renewal in vitro and inhibition of MAPK14 activation with a small molecule inhibitor may represent a novel approach to promote ex vivo expansion of hematopoietic stem cell (PMID:21198398) . This protein has 4 isoforms produced by alternative splicing.
Synonyms
Mitogen-activated protein kinase 14 (MAP kinase 14, MAPK 14) |Cytokine suppressive anti-inflammatory drug-binding protein (CSAID-binding protein, CSBP) |MAP kinase MXI2|MAX-interacting protein 2|Mitogen-activated protein kinase p38 alpha (MAP kinase p38 alpha) |Stress-activated protein kinase 2a (SAPK2a) |MAPK14|CSBP|CSBP1|CSBP2|CSPB1|MXI2|SAPK2A
Gene ID
1432
UniProt
Q16539
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Mitogen-activated protein kinase 14
Target
MAPK14
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Immunology, Cardiovascular, Metabolism, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
30-41 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
1-206aa

UniProtKB · Q16539

Mitogen-activated protein kinase 14

MK14_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q16539
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAPK14
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MAP kinase 14, MAPK 14
EC number
2.7.11.24
Processing
—
Secondary accessions
A6ZJ92, A8K6P4, B0LPH0, B5TY32, O60776, Q13083, Q14084, Q8TDX0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisStress responseTranscriptionTranscription regulation

Ligand

ATP-bindingNucleotide-binding

Cellular component

CytoplasmNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

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