2’-Fluoro-2’-deoxy-ara-A(Bz)-3’-phosphoramidite

2’-Fluoro-2’-deoxy-ara-A(Bz)-3’-phosphoramidite

• CAS Number: 329187-86-2
• UNSPSC Description: 2’-Fluoro-2’-deoxy-ara-A(Bz)-3’-phosphoramidite is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/2-fluoro-2-deoxy-ara-a-bz-3-phosphoramidite.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(C1=CC=CC=C1)NC2=NC=NC3=C2N=CN3[C@@H]4O[C@H](COC(C5=CC=C(OC)C=C5)(C6=CC=CC=C6)C7=CC=C(OC)C=C7)[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H]4F
• Molecular Weight: 875.92
• References & Citations: [1]Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported