Tos-PEG4-t-butyl ester

CAT:

804-HY-130422-01

Size:

50 mg

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Alternative Name: Tos-PEG4-Boc
CAS Number: 217817-01-1
UNSPSC Description: Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM[1].
Target Antigen: PROTAC Linkers
Type: Reference compound
Related Pathways: PROTAC
Field of Research: Cancer
Assay Protocol: https://www.medchemexpress.com/tos-peg4-t-butyl-ester.html
Purity: 97.44
Solubility: DMSO : 100 mg/mL (ultrasonic)
Smiles: O=C(OC(C)(C)C)CCOCCOCCOCCOS(=O)(C1=CC=C(C)C=C1)=O
Molecular Weight: 432.53
References & Citations: [1]Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.
Shipping Conditions: Room Temperature
Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
Clinical Information: No Development Reported

Cat	Name
HY-130422-01	Tos-PEG4-t-butyl ester
HY-130422-02	Tos-PEG4-t-butyl ester
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HY-132064-01	FmocNH-PEG4-t-butyl ester
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HY-132064-02	FmocNH-PEG4-t-butyl ester
HY-132067-02	Bis-PEG4-t-butyl ester
HY-W190966	t-Boc-Aminooxy-PEG4-t-butyl ester
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