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AZ5576

CAT: 0804-HY-143584-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-143584-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZ5576 is a potent and highly selective CDK9 inhibitor (IC50: [1][2].
CAS Number
2751721-40-9
UNSPSC
12352005
Target
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/az5576.html
Purity
99.86
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C([C@@H]1C[C@H](NC(C)=O)CCC1)NC2=NC=CC(C3=CC=C(F)C=C3OC)=C2
Molecular Formula
C21H24FN3O3
Molecular Weight
385.43
References & Citations
[1]Bernard Barlaam, et al. Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies. |[2]Hashiguchi T, et al., Cyclin-Dependent Kinase-9 Is a Therapeutic Target in MYC-Expressing Diffuse Large B-Cell Lymphoma. Mol Cancer Ther. 2019 Sep;18 (9) :1520-1532.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9

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