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AZ5576 racemate

CAT: 0931-T70953-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T70953-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1333468-05-5
Target
Bcl-2 Family, Others, c-Myc, CDK
Related Pathways
Others, Cell Cycle/Checkpoint, Apoptosis
Bioactivity
AZ5576 racemate is a racemic mixture of AZ5576 isomers. AZ5576 is a potent, highly selective, and orally bioavailable inhibitor of Cdk9 that inhibits Cdk9 enzyme activity with an IC50 <5nM and decreases phosphorlyation of Ser2-RNAPII in cells with an IC50 of 96nM. In the MLL-fusion containing acute myeloid leukemia (AML) line, MV411, short-term treatment with AZ5576 led to a rapid dose-dependent decrease in pSer2-RNAPII with concomitant loss of Mcl1 mRNA and protein, resulting in the cleavage and activation of caspase 3 and loss of cell viability.
Smiles
O(C)C1=C(C=2C=C(NC(=O)[C@@H]3C[C@H](NC(C)=O)CCC3)N=CC2)C=CC(F)=C1
Molecular Formula
C21H24FN3O3
Molecular Weight
385.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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