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(+) -Norcisapride

CAT: 0804-HY-100243-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100243-01Size:1 mg
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Description
(+) -Norcisapride (Ticalopride) is a potent 5-HT4 agonist and a 5-HT3 antagonist. (+) -Norcisapride has activity in animals models of constipation[1].
CAS Number
202590-69-0
Product Name Alternative
Ticalopride
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/plus-norcisapride.html
Purity
99.32
Solubility
DMSO : 40 mg/mL (ultrasonic)
Smiles
O=C(N[C@H]1[C@@H](OC)CNCC1)C2=CC(Cl)=C(N)C=C2OC
Molecular Formula
C14H20ClN3O3
Molecular Weight
313.78
References & Citations
[1]Liming Shao, et al. mu-Opioid/5-HT4 dual pharmacologically active agents-efforts towards an effective opioid analgesic with less GI and respiratory side effects (Part I) . Bioorg Med Chem Lett. 2009 Oct 1;19 (19) :5679-83.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Apolipoprotein D; lactoferrin

Chemical Information

Norcisapride, (+)-
CAS Number202590-69-0
PubChem CID216236
IUPAC Name4-amino-5-chloro-2-methoxy-N-[(3S,4R)-3-methoxypiperidin-4-yl]benzamide
Molecular FormulaC14H20ClN3O3
Molecular Weight313.78
XLogP0.8
Topological Polar Surface Area85.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count21
Formal Charge0
Complexity358
SMILES
CO[C@H]1CNCC[C@H]1NC(=O)C2=CC(=C(C=C2OC)N)Cl
InChI
InChI=1S/C14H20ClN3O3/c1-20-12-6-10(16)9(15)5-8(12)14(19)18-11-3-4-17-7-13(11)21-2/h5-6,11,13,17H,3-4,7,16H2,1-2H3,(H,18,19)/t11-,13+/m1/s1
InChIKey
OMLDMGPCWMBPAN-YPMHNXCESA-N
Chemical Structure
2D Structure
2D structure of Norcisapride, (+)-
CAS: 202590-69-0
CID: 216236
Formula: C14H20ClN3O3
MW: 313.78
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight313.78
XLogP30.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass313.1193192
Monoisotopic Mass313.1193192
Topological Polar Surface Area85.6 Ų
Heavy Atom Count21
Formal Charge0
Complexity358
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19277509-01Norcisapride
BUP03973-01(Rac) -Norcisapride
MBS5810672(Rac)-Norcisapride

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