(+)-Norcisapride

• UNSPSC Description:

  (+)-Norcisapride (Ticalopride) is a potent 5-HT4 agonist and a 5-HT3 antagonist. (+)-Norcisapride has activity in animals models of constipation[1].

• Target Antigen:

  5-HT Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/plus-norcisapride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N[C@H]1[C@@H](OC)CNCC1)C2=CC(Cl)=C(N)C=C2OC

• Molecular Weight:

  313.78

• References & Citations:

  [1]Liming Shao, et al. mu-Opioid/5-HT4 dual pharmacologically active agents-efforts towards an effective opioid analgesic with less GI and respiratory side effects (Part I). Bioorg Med Chem Lett. 2009 Oct 1;19(19):5679-83.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  202590-69-0