CHMFL-PI4K-127

CHMFL-PI4K-127

• CAS Number: 2377604-81-2
• UNSPSC Description: CHMFL-PI4K-127 (compound 15g) is an orally active, potent and high selective PfPI4K (Plasmodium falciparum PI4K kinase) inhibitor, with an IC50 of 0.9 nM. CHMFL-PI4K-127 exhibits potent activity against 3D7 Plasmodium falciparum, with an EC50 of 25.1 nM. CHMFL-PI4K-127 shows antimalaria efficacy[1].
• Target Antigen: PI3K; PI4K
• Type: Reference compound
• Related Pathways: PI3K/Akt/mTOR
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/chmfl-pi4k-127.html
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: O=C(C1=CN=CC(C2=CC(NS(=O)(C3=CC=CC=C3)=O)=C(Cl)N=C2)=C1)NC
• Molecular Weight: 402.85
• References & Citations: [1]6'-chloro-N-methyl-5'-(phenylsulfonamido)-[3,3'-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium. Eur J Med Chem. 2020 Feb 15;188:112012.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported