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Mycothiazole

CAT: 0804-HY-N12887Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N12887Size:1 Each
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Description
Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC50 is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans[1].
CAS Number
114582-75-1
UNSPSC
12352005
Target
Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Others
Assay Protocol
https://www.medchemexpress.com/mycothiazole.html
Solubility
10 mM in DMSO
Smiles
COC(NCCC(/C=C\C[C@H](O)C(C)(C1=NC(C/C=C\CC=C)=CS1)C)=C)=O
Molecular Formula
C22H32N2O3S
Molecular Weight
404.57
References & Citations
[1]Dutta N, et al., Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging. Geroscience. 2024 Apr 3.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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