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Scoulerine

CAT: 0804-HY-N1255-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N1255-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Scoulerine ((-) -Scoulerine), an isoquinoline alkaloid, is a potent antimitotic compound. Scoulerine is also an inhibitor of BACE1 (β-site amyloid precursor protein cleaving enzyme 1) . Scoulerine inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells[1].
CAS Number
6451-73-6
Product Name Alternative
(-) -Scoulerine; Discretamine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Beta-secretase; Microtubule/Tubulin
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/scoulerine.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C(OC)C=C(CCN2CC3=C(O)C(OC)=CC=C3C[C@]24[H])C4=C1
Molecular Formula
C19H21NO4
Molecular Weight
327.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Habartova K, et al. Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells. Sci Rep. 2018;8 (1) :4829. Published 2018 Mar 19.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
BACE1

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