Products for Research Use Only
RegisterLogin

Tandospirone-d8

CAT: 0804-HY-14558SSize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-14558SSize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Tandospirone-d8 (SM-3997-d8) is deuterium labeled Tandospirone. Tandospirone (SM-3997) is a potent and selective 5-HT1A receptor partial agonist, with a Ki of 27 nM. Tandospirone has anxiolytic and antidepressant activities. Tandospirone can be used for the research of the central nervous system disorders and the underlying mechanisms[1][2][3][4].
CAS Number
1794835-73-6
Product Name Alternative
SM-3997-d8
UNSPSC
12352005
Target
5-HT Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C1[C@]2([H])[C@]([C@H]3CC[C@@H]2C3)([H])C(N1C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])N(CC4)CCN4C5=NC=CC=N5)=O
Molecular Formula
C21H21D8N5O2
Molecular Weight
391.54
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Hamik A, et al. Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol Psychiatry. 1990 Jul 15;28 (2) :99-109.|[3]Xuefei Huang, et al. Role of tandospirone, a 5-HT1A receptor partial agonist, in the treatment of central nervous system disorders and the underlying mechanisms. Oncotarget. 2017 Nov 24; 8 (60) : 102705–102720.|[4]Kyoko Nishitsuji, et al. The pharmacokinetics and pharmacodynamics of tandospirone in rats exposed to conditioned fear stress. Eur Neuropsychopharmacol. 2006 Jul;16 (5) :376-82.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor

Chemical Information

Tandospirone-d8
CAS Number1794835-73-6
PubChem CID119090981
IUPAC Name(1S,2R,6S,7R)-4-[1,1,2,2,3,3,4,4-octadeuterio-4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-4-azatricyclo[5.2.1.02,6]decane-3,5-dione
Molecular FormulaC21H29N5O2
Molecular Weight391.5
XLogP1.9
Topological Polar Surface Area69.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count28
Formal Charge0
Complexity572
SMILES
[2H]C([2H])(C([2H])([2H])C([2H])([2H])N1C(=O)[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C1=O)C([2H])([2H])N4CCN(CC4)C5=NC=CC=N5
InChI
InChI=1S/C21H29N5O2/c27-19-17-15-4-5-16(14-15)18(17)20(28)26(19)9-2-1-8-24-10-12-25(13-11-24)21-22-6-3-7-23-21/h3,6-7,15-18H,1-2,4-5,8-14H2/t15-,16+,17+,18-/i1D2,2D2,8D2,9D2
InChIKey
CEIJFEGBUDEYSX-MLALYRAXSA-N
Chemical Structure
2D Structure
2D structure of Tandospirone-d8
CAS: 1794835-73-6
CID: 119090981
Formula: C21H29N5O2
MW: 391.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight391.5
XLogP31.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass391.28233915
Monoisotopic Mass391.28233915
Topological Polar Surface Area69.6 Ų
Heavy Atom Count28
Formal Charge0
Complexity572
Isotope Atom Count8
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-14558-01Tandospirone
HY-14558RTandospirone (Standard)
HY-B0061-01Tandospirone (citrate)
HY-110053-01Tandospirone (hydrochloride)
HY-W096184-01Tandospirone impurity 4
HY-W096183-01Tandospirone impurity 3
HY-157074STandospirone Acid Metabolite-d6
HY-W096184RTandospirone Impurity 4 (Standard)
HY-W096183RTandospirone impurity 3 (Standard)
HY-15440ASFostemsavir-d8

Alternative Products

CatalogName
TRC-T006432-50MGTandospirone-d8
B1199-5.1Tandospirone
A13293-200Tandospirone 200mg
A13293-50Tandospirone 50mg
A13293-25Tandospirone 25mg
A13293-2Tandospirone 2mg
E4851-5mgTandospirone citrate

Popular Products