Spectinomycin

CAT: 0804-HY-B1828Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-B1828Size:1 Each
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Description
Spectinomycin is a broad-spectrum antibiotic and inhibits the growth of a variety of gram-positive and gram-negative organisms. Spectinomycin acts by selectively targeting to the bacterial ribosome and interrupting protein synthesis. Spectinomycin is also a noncompetitive inhibitor of td intron RNA[1][2][3][4][5].
CAS Number
[1695-77-8]
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/spectinomycin.html
Solubility
10 mM in DMSO
Smiles
O=C1C[C@@H](C)O[C@@]2([H])O[C@@]3([H])[C@]([C@@H](NC)[C@@H](O)[C@@H](NC)[C@@H]3O)([H])O[C@]21O
Molecular Formula
C14H24N2O7
Molecular Weight
332.35
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Davies J, et al. Inhibition of protein synthesis by spectinomycin. Science. 1965 Sep 3;149 (3688) :1096-8. |[2]Brink MF, et al. Spectinomycin interacts specifically with the residues G1064 and C1192 in 16S rRNA, thereby potentially freezing this molecule into an inactive conformation. Nucleic Acids Res. 1994 Feb 11;22 (3) :325-31. |[3]Park IK, et al. Spectinomycin inhibits the self-splicing of the group 1 intron RNA. Biochem Biophys Res Commun. 2000 Mar 16;269 (2) :574-9. |[4]Khan EA, et al. Safety evaluation study of lincomycin and spectinomycin hydrochloride intramuscular injection in chickens. Toxicol Rep. 2022 Jan 29;9:204-209. |[5]Madhura DB, et al. Pharmacokinetic profile of spectinomycin in rats. Pharmazie. 2013 Aug;68 (8) :675-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Aminoglycoside
Citation 01
Vet Microbiol. 2024 May:292:110046.|BMC Vet Res. 2022 Jul 12;18 (1) :270.|Patent. US20200368199A1.

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