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(R) -Merimepodib

CAT: 0804-HY-13986A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13986A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -Merimepodib is the isomer of Merimepodib , and can be used as an experimental control. Merimepodib (VX-497) is a noncompetitive and oral inhibitor of inosine monophosphate dehydrogenase (IMPDH) with broad spectrum antiviral activities.
CAS Number
2748420-50-8
Product Name Alternative
(R) -VX-497; (R) -MMPD
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
IMPDH
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/r-merimepodib.html
Purity
96.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=C(C2=CN=CO2)C=CC(NC(NC3=CC(CNC(O[C@@H]4CCOC4)=O)=CC=C3)=O)=C1
Molecular Formula
C23H24N4O6
Molecular Weight
452.46
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Jain J, et al. VX-497: a novel, selective IMPDH inhibitor and immunosuppressive agent. J Pharm Sci. 2001 May;90 (5) :625-37.|[2]Decker CJ, et al. The novel IMPDH inhibitor VX-497 prolongs skin graft survival and improves graft versus host disease in mice. Drugs Exp Clin Res. 2001;27 (3) :89-95.|[3]Markland W, et al. Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon. Antimicrob Agents Chemother. 2000 Apr;44 (4) :859-66.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

(R)-Merimepodib
CAS Number2748420-50-8
PubChem CID6335166
IUPAC Name[(3R)-oxolan-3-yl] N-[[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]methyl]carbamate
Molecular FormulaC23H24N4O6
Molecular Weight452.5
XLogP2.1
Topological Polar Surface Area124
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Heavy Atom Count33
Formal Charge0
Complexity652
SMILES
COC1=C(C=CC(=C1)NC(=O)NC2=CC=CC(=C2)CNC(=O)O[C@@H]3CCOC3)C4=CN=CO4
InChI
InChI=1S/C23H24N4O6/c1-30-20-10-17(5-6-19(20)21-12-24-14-32-21)27-22(28)26-16-4-2-3-15(9-16)11-25-23(29)33-18-7-8-31-13-18/h2-6,9-10,12,14,18H,7-8,11,13H2,1H3,(H,25,29)(H2,26,27,28)/t18-/m1/s1
InChIKey
JBPUGFODGPKTDW-GOSISDBHSA-N
Chemical Structure
2D Structure
2D structure of (R)-Merimepodib
CAS: 2748420-50-8
CID: 6335166
Formula: C23H24N4O6
MW: 452.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight452.5
XLogP32.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Exact Mass452.16958450
Monoisotopic Mass452.16958450
Topological Polar Surface Area124 Ų
Heavy Atom Count33
Formal Charge0
Complexity652
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
B2705-25Merimepodib
A21139-50Merimepodib 50mg
A21139-25Merimepodib 25mg
A21139-10Merimepodib 10mg
A21139-5Merimepodib 5mg
OR1067229-01(R) -Merimepodib
A21139-100Merimepodib 100mg
A21139-1Merimepodib 1mg
A21139-10mM-DMerimepodib 10mM * 1mL in DMSO

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