Products for Research Use Only
RegisterLogin

GZNL-P36

CAT: 0804-HY-162484Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-162484Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
GZNL-P36 is an orally active inhibitor for SARS-CoV-2 papain-like protease (PLpro), with an IC50 of 6.45 nM. GZNL-P36 inhibits SARS-CoV and its variants with EC50 range from 58.2 nM to 2.66 μM. GZNL-P36 exhibits a peak plasma concentration Cmax of 549 ng/mL, a half-life T1/2 of 1.45 h and a bioavailability of 74.7% in CD-1 mouse. GZNL-P36 exhibits antiviral activity in SARS-CoV-2 XXB.1 infection in mouse[1].
CAS Number
3089845-68-8
UNSPSC
12352005
Target
SARS-CoV; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gznl-p36.html
Solubility
10 mM in DMSO
Smiles
CN1C2=CC=C(C3(CC3)NC(C4=CC(N5CC(C6)N(C)C6C5)=CC=C4C)=O)C7=C2C(C1=O)=CC=C7
Molecular Formula
C29H30N4O2
Molecular Weight
466.57
References & Citations
[1]Lu Y, et al., Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19[J]. bioRxiv, 2024: 2024.04. 03.587743.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
T209677-01GZNL-P36
052030EIF3 p36
163088Anti HIV p36 Pab
AP-308-UEndothelial Cells (P36), Peptide Aptamer, unlabeled
AP-308-BEndothelial Cells (P36), Peptide Aptamer, Biotinylated
MBS596166-01Plasmodium Falciparum MSP1-P36 Recombinant Protein
AP-308-FEndothelial Cells (P36), Peptide Aptamer, FITC labelled
MBS1318773-01Recombinant Taenia saginata Small heat shock protein p36
MBS1085977-01Recombinant Enterobacteria phage Ox2 Tail fiber protein p36 (36)
MBS1204713-01Recombinant Enterobacteria phage T2 Tail fiber protein p36 (36)

Popular Products