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GZNL-P36

CAT: 0931-T209677-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T209677-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
SARS-CoV, Virus Protease
Related Pathways
Microbiology/Virology
Bioactivity
GZNL-P36 is an orally active inhibitor of SARS-CoV-2 papain-like protease (PLpro), with an IC50 of 6.45 nM. It effectively inhibits SARS-CoV and its variants, showing an EC50 ranging from 58.2 nM to 2.66 μM. In CD-1 mouse models, GZNL-P36 reaches a maximum plasma concentration (Cmax) of 549 ng/mL, with a half-life (T1/2) of 1.45 hours and a bioavailability of 74.7%. Additionally, GZNL-P36 exhibits antiviral activity in mice infected with SARS-CoV-2 XXB.1.
Molecular Formula
C29H30N4O2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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